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The RNA-seq transcriptome analysis revealed that disulfiram induces oxidative stress, redox imbalance, metal acquisition, and the biosynthesis of pantothenate, coenzyme A, thiamine, menaquinone, siderophores/metallophores, and bacillithiol

Jaja SI, Aigbe PE, Gbenebitse S, Temiye EO

Mice were sacrificed by cervical dislocation after 2 weeks of treatment

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Biochemical studies reveal that SLC31 family members assemble into functional trimers, each comprising nine transmembrane domains, enabling the selective inward flow of Cu(I) along concentration gradients [8]